recombinantPDGFβ,human,0.1mg

Producedinamammaliancellline.

Alternativename:
pdgf
PDGF2
becaplermin
proto-oncogenec-Sis

Sendanemailtoinfo@U-proteinexpress.comforbulkquantities

Productdescription
HumanPDGFb,plateletderivedgrowthfactor(pdgf),isadimericprotein.ItcanformhomodimersofPDGFborheterodimerswithPDGFa.Itisinvolvedintheregulationofembryonicdevelopment,cellproliferation,cellmigration,survivalandchemotaxis.Potentmitogenforcellsofmesenchymalorigin.Requiredfornormalproliferationandrecruitmentofpericytesandvascularsmoothmusclecellsinthecentralnervoussystem,skin,lung,heartandplacenta.Requiredfornormalbloodvesseldevelopment,andfornormaldevelopmentofkidneyglomeruli.Playsanimportantroleinwoundhealing.MutationsinPDGFbareassociatedwithmeningioma.Reciprocaltranslocationsbetweenchromosomes22and7,atsiteswherethisgeneandthatforCOL1A1arelocated,areassociatedwithaparticulartypeofskintumorcalleddermatofibrosarcomaprotuberansresultingfromunregulatedexpressionofgrowthfactor.

U-Protein Express BV是一家具有多年重组蛋白生产经验的专业CRO公司。At-Protein Express BV通过其基于人类胚胎肾细胞（HEK293E）的专利r-PEx瞬时表达平台（正在申请专利）产生完全翻译后修饰的哺乳动物蛋白质。r-PEx的瞬时表达技术比传统的方法快得多，并且提供了大量具有生物活性的重组蛋白。此外，我们还产生了一种新的专有HEK293细胞系（HEK293ES，正在申请专利），用于生产适合通过X射线晶体学进行结构测定的重组蛋白。